THE WHY BEHIND THE GAME
Indianapolis Colts vs San Francisco 49ers.
Every meeting since 1999, regular season and playoffs.
The Colts and 49ers have met 7 times since 2001. Oddly, the road team has won 5 of the 7 decided meetings. The most recent meeting, in 2025, went to the 49ers, 48–27.
- Regular season
- IND 5 · SF 2
- Playoffs
- No meetings
- Home record
- IND 2–2 · SF 0–3
- Points per meeting
- IND 25.3 · SF 21.9
- Current streak
- SF won the last meeting
- IND biggest win
- By 25 · IND 28, SF 3 (2005)
- SF biggest win
- By 21 · SF 48, IND 27 (2025)
Every meeting
| Season | Game | Score | Winner |
|---|---|---|---|
| 2025 | Week 16 | SF 48, IND 27 | SF |
| 2021 | Week 7 | IND 30, SF 18 | IND |
| 2017 | Week 5 | SF 23, IND 26 (OT) | IND |
| 2013 | Week 3 | IND 27, SF 7 | IND |
| 2009 | Week 8 | SF 14, IND 18 | IND |
| 2005 | Week 5 | IND 28, SF 3 | IND |
| 2001 | Week 11 | SF 40, IND 21 | SF |
Results through (Eastern time).
From WHYNFL's results archive, which begins in 1999. Regular season and playoffs, counted by franchise: Raiders games include Oakland, Chargers games San Diego, Rams games St. Louis.