Final · Kickoff
2021 Regular season · Week 7 · Levi's Stadium · Sunday Night
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2021 regular season
The Indianapolis Colts beat the San Francisco 49ers 30–18 on the road at Levi's Stadium in Week 7 of the 2021 regular season on October 24, 2021.
The result moved the Colts to 3–4 and dropped the 49ers to 2–4. It was the 49ers’ fourth straight loss. The Colts finished 2021 at 9–8 and missed the playoffs. The 49ers finished 2021 at 10–7 and lost in the NFC Championship Game.
In their previous meeting, the Indianapolis Colts won 26–23 on October 8, 2017. When they met again, the San Francisco 49ers won 48–27 on December 22, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Colts lead the series 5–1 after meeting No. 6 since 2001 Full series history
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
Shane Steichen said the starting defensive end will miss time, and Jeremy Fowler reported a three-to-four-week absence for a pass rush that has produced just 1.5 sacks from its edge group.
