Final · Kickoff
2025 Regular season · Week 16 · Lucas Oil Stadium · Monday Night
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
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The San Francisco 49ers beat the Indianapolis Colts 48–27 on the road at Lucas Oil Stadium in Week 16 of the 2025 regular season on December 22, 2025.
The result moved the 49ers to 11–4 and dropped the Colts to 8–7. It was the 49ers’ fifth straight win. It was the Colts’ fifth straight loss. The 49ers finished 2025 at 12–5 and lost in the Divisional round. The Colts finished 2025 at 8–9 and missed the playoffs. The 49ers’ 48 points were their most in any game of 2025.
In their previous meeting, the Indianapolis Colts won 30–18 on October 24, 2021.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Colts lead the series 5–2 after meeting No. 7 since 2001 Full series history
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
Shane Steichen said the starting defensive end will miss time, and Jeremy Fowler reported a three-to-four-week absence for a pass rush that has produced just 1.5 sacks from its edge group.
