The veteran pulled up in the third quarter of Sunday's win at Seattle, leaving unbeaten San Francisco with four healthy receivers by the final whistle.
San Francisco won a seven-turnover game in Seattle when Cooper Kupp was ruled a yard short on the Seahawks' last chance, and Gracen Halton scored on a fumble in the end zone.
Mykel Williams makes his season debut for unbeaten San Francisco, Nick Bosa misses a third game, and Arizona keeps Harrison out while his trade is completed.
Ravens linebacker Trenton Simpson, Jets safety Minkah Fitzpatrick and Broncos guard Ben Powers drew the largest fines, and five players were docked for hip-drop tackles.
The Chargers coach rejected any change after the loss in Seattle, and Justin Herbert backed his play-caller as the offense keeps stalling early in games.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
