Final · Kickoff
2016 Regular season · Week 6 · New Era Field
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2016 regular season
The Buffalo Bills beat the San Francisco 49ers 45–16 at home at New Era Field in Week 6 of the 2016 regular season on October 16, 2016.
No other game of Week 6 was decided by as many points.
The result moved the Bills to 4–2 and dropped the 49ers to 1–5. It was the Bills’ fourth straight win. It was the 49ers’ fifth straight loss. The 49ers finished 2016 at 2–14 and missed the playoffs. The Bills finished 2016 at 7–9 and missed the playoffs. The Bills’ 45 points were their most in any game of 2016.
In their previous meeting, the San Francisco 49ers won 45–3 on October 7, 2012. When they met again, the Buffalo Bills won 34–24 on December 7, 2020.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series 49ers lead the series 3–2 after meeting No. 5 since 2001 Full series history
Buffalo heads to Los Angeles for Monday night thin at receiver after Palmer hurt his shoulder in practice, and rookie Skyler Bell is set for his NFL debut.
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
The Bills safety waved off the Patriots receiver as a practice-squad player after Sunday’s 29–26 loss. New England’s coach answered by pointing to how often Gardner-Johnson has changed teams.
