Final · Kickoff
2021 Regular season · Week 16 · State Farm Stadium · Saturday
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2021 regular season
The Indianapolis Colts beat the Arizona Cardinals 22–16 on the road at State Farm Stadium in Week 16 of the 2021 regular season on December 25, 2021. It was a one-score game at the finish, decided by 6 points.
The result moved the Colts to 9–6 and dropped the Cardinals to 10–5. It was the Colts’ third straight win. It was the Cardinals’ third straight loss. The Colts finished 2021 at 9–8 and missed the playoffs. The Cardinals finished 2021 at 11–6 and lost in the Wild Card round.
In their previous meeting, the Arizona Cardinals won 16–13 on September 17, 2017. When they met again, the Indianapolis Colts won 31–27 on October 12, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Colts lead the series 3–2 after meeting No. 5 since 2005 Full series history
Line judge Jeff Seeman will sit two games and referee Adrian Hill one after on-camera confrontations with players during Week 4.
Shane Steichen said the starting defensive end will miss time, and Jeremy Fowler reported a three-to-four-week absence for a pass rush that has produced just 1.5 sacks from its edge group.
Dan Quinn confirmed Lane will miss the season with a fractured and dislocated ankle. Washington placed the receiver and returner on IR October 6.
