Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
The Los Angeles Rams beat the San Francisco 49ers 42–26 on the road at Levi's Stadium in Week 10 of the 2025 regular season on November 9, 2025.
The 68 combined points were the most in any game of Week 10.
The result moved the Rams to 7–2 and dropped the 49ers to 6–4. It was the Rams’ fourth straight win. The Rams finished 2025 at 12–5 and lost in the NFC Championship Game. The 49ers finished 2025 at 12–5 and lost in the Divisional round.
In their previous meeting, the San Francisco 49ers won 26–23 on October 2, 2025. When they met again, the San Francisco 49ers won 27–7 on September 10, 2026. The teams split their two 2025 meetings.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series 49ers lead the series 30–24–1 after meeting No. 55 since 1999 Full series history
Buffalo heads to Los Angeles for Monday night thin at receiver after Palmer hurt his shoulder in practice, and rookie Skyler Bell is set for his NFL debut.
Ravens linebacker Trenton Simpson, Jets safety Minkah Fitzpatrick and Broncos guard Ben Powers drew the largest fines, and five players were docked for hip-drop tackles.
