Final · Kickoff
2021 Regular season · Week 5 · State Farm Stadium
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2021 regular season
The Arizona Cardinals beat the San Francisco 49ers 17–10 at home at State Farm Stadium in Week 5 of the 2021 regular season on October 10, 2021. It was a one-score game at the finish, decided by 7 points.
The 27 combined points were the fewest in any game of Week 5.
The result moved the Cardinals to 5–0 and dropped the 49ers to 2–3. It was the Cardinals’ fifth straight win. It was the 49ers’ third straight loss. The 49ers finished 2021 at 10–7 and lost in the NFC Championship Game. The Cardinals finished 2021 at 11–6 and lost in the Wild Card round. The 49ers’ 10 points were their fewest in any game of 2021.
In their previous meeting, the San Francisco 49ers won 20–12 on December 26, 2020. When they met again, the Arizona Cardinals won 31–17 on November 7, 2021.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series 49ers lead the series 22–19 after meeting No. 41 since 1999 Full series history
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
Line judge Jeff Seeman will sit two games and referee Adrian Hill one after on-camera confrontations with players during Week 4.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
