Final · Kickoff
2025 Regular season · Week 3 · Levi's Stadium
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
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The San Francisco 49ers beat the Arizona Cardinals 16–15 at home at Levi's Stadium in Week 3 of the 2025 regular season on September 21, 2025. The final margin was a single point.
The result moved the 49ers to 3–0 and dropped the Cardinals to 2–1. It was the 49ers’ third straight win. The Cardinals finished 2025 at 3–14 and missed the playoffs. The 49ers finished 2025 at 12–5 and lost in the Divisional round.
In their previous meeting, the Arizona Cardinals won 47–24 on January 5, 2025. When they met again, the San Francisco 49ers won 41–22 on November 16, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series 49ers lead the series 27–22 after meeting No. 49 since 1999 Full series history
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
Line judge Jeff Seeman will sit two games and referee Adrian Hill one after on-camera confrontations with players during Week 4.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
