Philadelphia's third running back to go down this season is expected to miss multiple weeks, and the Eagles are hoping Saquon Barkley is close to returning from his hamstring injury.
Jefferson returns from the ankle sprain that cost him the win over Miami, while Minnesota holds Addison and Odell Beckham Jr. out against the Saints.
A Jaguars return touchdown was wiped out by offsetting flags, and the Eagles linebacker and Jacksonville defensive end were sent off before the first scrimmage play.
Both receivers were questionable after injuries in the loss to Jacksonville, with Chase in the concussion protocol, but are expected to face the winless Dolphins.
Two days after Ditka's death at 86, Chicago honors its Hall of Fame tight end and Super Bowl XX coach in the 214th meeting of the NFL's oldest rivalry.
Tennessee values the veteran running back's leadership and his effect on Cam Ward more than a deadline return, even at 0-4 with Pollard in the last year of his deal.
Philadelphia would rather hold the roster spot than move the right tackle to the retired list, while several million dollars of his bonus are still being sorted out.
Jaylen Warren carries Pittsburgh's backfield for a third straight game, while Indianapolis gets its veteran receiver back but loses Darius Slayton.
Atlanta's left tackle is expected to play through a groin injury on Sunday night, and Baltimore's two questionable starters should join him on the field.
Los Angeles dresses its top receiver despite a foot injury that kept him out of practice all week, while Denver plays without both starting cornerbacks.
