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The quarterback acquired from Minnesota is active for the first time, with New York carrying only two passers at Northwest Stadium.
Three Philadelphia players were ruled out and a starting guard left hurt during the 19-17 loss to Jacksonville, deepening an injury list that already held Saquon Barkley and DeVonta Smith.
Jefferson returns from the ankle sprain that cost him the win over Miami, while Minnesota holds Addison and Odell Beckham Jr. out against the Saints.
A Jaguars return touchdown was wiped out by offsetting flags, and the Eagles linebacker and Jacksonville defensive end were sent off before the first scrimmage play.
Both receivers were questionable after injuries in the loss to Jacksonville, with Chase in the concussion protocol, but are expected to face the winless Dolphins.
Two days after Ditka's death at 86, Chicago honors its Hall of Fame tight end and Super Bowl XX coach in the 214th meeting of the NFL's oldest rivalry.
Tennessee values the veteran running back's leadership and his effect on Cam Ward more than a deadline return, even at 0-4 with Pollard in the last year of his deal.
Philadelphia would rather hold the roster spot than move the right tackle to the retired list, while several million dollars of his bonus are still being sorted out.
Jaylen Warren carries Pittsburgh's backfield for a third straight game, while Indianapolis gets its veteran receiver back but loses Darius Slayton.
Atlanta's left tackle is expected to play through a groin injury on Sunday night, and Baltimore's two questionable starters should join him on the field.
