Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
The Indianapolis Colts beat the Buffalo Bills 41–15 on the road at New Era Field in Week 11 of the 2021 regular season on November 21, 2021.
No other game of Week 11 was decided by as many points.
The result moved the Colts to 6–5 and dropped the Bills to 6–4. It was the Colts’ third straight win. The Colts finished 2021 at 9–8 and missed the playoffs. The Bills finished 2021 at 11–6 and lost in the Divisional round.
In their previous meeting, the Buffalo Bills won 27–24 on January 9, 2021. When they met again, the Buffalo Bills won 30–20 on November 10, 2024.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Colts lead the series 10–5 after meeting No. 15 since 1999 Full series history
Buffalo heads to Los Angeles for Monday night thin at receiver after Palmer hurt his shoulder in practice, and rookie Skyler Bell is set for his NFL debut.
The Bills safety waved off the Patriots receiver as a practice-squad player after Sunday’s 29–26 loss. New England’s coach answered by pointing to how often Gardner-Johnson has changed teams.
Shane Steichen said the starting defensive end will miss time, and Jeremy Fowler reported a three-to-four-week absence for a pass rush that has produced just 1.5 sacks from its edge group.
