Final · Kickoff
2022 Regular season · Week 5 · Bank of America Stadium
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2022 regular season
The San Francisco 49ers beat the Carolina Panthers 37–15 on the road at Bank of America Stadium in Week 5 of the 2022 regular season on October 9, 2022.
The result moved the 49ers to 3–2 and dropped the Panthers to 1–4. The 49ers finished 2022 at 13–4 and lost in the NFC Championship Game. The Panthers finished 2022 at 7–10 and missed the playoffs.
In their previous meeting, the San Francisco 49ers won 51–13 on October 27, 2019. When they met again, the San Francisco 49ers won 20–9 on November 24, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Panthers lead the series 10–5 after meeting No. 15 since 1999 Full series history
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
Surtain and Moss are out against the Chargers; Bryant is on injured reserve, and Lil’Jordan Humphrey has joined Denver’s active roster.
