Final · Kickoff
2025 Regular season · Week 2 · Mercedes-Benz Superdome
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2025 regular season
The San Francisco 49ers beat the New Orleans Saints 26–21 on the road at Mercedes-Benz Superdome in Week 2 of the 2025 regular season on September 14, 2025. It was a one-score game at the finish, decided by 5 points.
The result moved the 49ers to 2–0 and dropped the Saints to 0–2. The 49ers finished 2025 at 12–5 and lost in the Divisional round. The Saints finished 2025 at 6–11 and missed the playoffs.
In their previous meeting, the San Francisco 49ers won 13–0 on November 27, 2022.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Saints lead the series 12–9 after meeting No. 21 since 1999 Full series history
New Orleans also called up receiver Cedric Tillman and tackle Easton Kilty from the practice squad for Sunday's home game against Minnesota.
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
The fullback has a hyperextended knee and a bone bruise from Sunday's win over Denver, and Kyle Shanahan will spread his role among the tight ends for the trip to Seattle.
