Final · Kickoff
2021 Regular season · Week 1 · Lucas Oil Stadium
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2021 regular season
The Seattle Seahawks beat the Indianapolis Colts 28–16 on the road at Lucas Oil Stadium in Week 1 of the 2021 regular season on September 12, 2021.
The result moved the Seahawks to 1–0 and dropped the Colts to 0–1. The Seahawks finished 2021 at 7–10 and missed the playoffs. The Colts finished 2021 at 9–8 and missed the playoffs.
In their previous meeting, the Seattle Seahawks won 46–18 on October 1, 2017. When they met again, the Seattle Seahawks won 18–16 on December 14, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Series tied 3–3 after meeting No. 6 since 2000 Full series history
Ravens linebacker Trenton Simpson, Jets safety Minkah Fitzpatrick and Broncos guard Ben Powers drew the largest fines, and five players were docked for hip-drop tackles.
San Francisco needed the spot to bring back Ogbo Okoronkwo, ending the four-time Pro Bowl pass rusher's stay after less than two weeks.
The Chargers coach rejected any change after the loss in Seattle, and Justin Herbert backed his play-caller as the offense keeps stalling early in games.
