Final · Kickoff
2021 Regular season · Week 1 · Nissan Stadium
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2021 regular season
The Arizona Cardinals beat the Tennessee Titans 38–13 on the road at Nissan Stadium in Week 1 of the 2021 regular season on September 12, 2021.
The result moved the Cardinals to 1–0 and dropped the Titans to 0–1. The Cardinals finished 2021 at 11–6 and lost in the Wild Card round. The Titans finished 2021 at 12–5 and lost in the Divisional round. The Cardinals’ 38 points were their most in any game of 2021.
In their previous meeting, the Arizona Cardinals won 12–7 on December 10, 2017. When they met again, the Tennessee Titans won 22–21 on October 5, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Cardinals lead the series 4–1 after meeting No. 5 since 2005 Full series history
Arizona will keep its 2024 first-round receiver out of Sunday's game against Detroit while the deal is completed, and the remaining dispute is reportedly over the year of a second-round pick.
Line judge Jeff Seeman will sit two games and referee Adrian Hill one after on-camera confrontations with players during Week 4.
Arizona left tackle Paris Johnson Jr. tore his biceps late in the loss to the Giants and will miss the rest of the season, coach Mike LaFleur said.
