Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
The Buffalo Bills beat the Carolina Panthers 31–14 at home at New Era Field in Week 15 of the 2021 regular season on December 19, 2021.
The result moved the Bills to 8–6 and dropped the Panthers to 5–9. It was the Panthers’ fourth straight loss. The Panthers finished 2021 at 5–12 and missed the playoffs. The Bills finished 2021 at 11–6 and lost in the Divisional round.
In their previous meeting, the Carolina Panthers won 9–3 on September 17, 2017. When they met again, the Buffalo Bills won 40–9 on October 26, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Bills lead the series 4–2 after meeting No. 6 since 2001 Full series history
Buffalo heads to Los Angeles for Monday night thin at receiver after Palmer hurt his shoulder in practice, and rookie Skyler Bell is set for his NFL debut.
The Bills safety waved off the Patriots receiver as a practice-squad player after Sunday’s 29–26 loss. New England’s coach answered by pointing to how often Gardner-Johnson has changed teams.
Carolina’s second-year receiver came within one catch and nine yards of two franchise records, and the defense stopped Detroit on fourth-and-13 to seal the win.
