Final · Kickoff
2021 Regular season · Week 12 · Mercedes-Benz Superdome · Thursday Night
Historical final score from the WHYNFL results archive. WHYNFL preserves the team labels of the time and converts supplied Eastern kickoff times. Team links open today's franchise hubs. Historical box scores and play-by-play are not supplied.
Explore the 2021 regular season
The Buffalo Bills beat the New Orleans Saints 31–6 on the road at Mercedes-Benz Superdome in Week 12 of the 2021 regular season on November 25, 2021.
The result moved the Bills to 7–4 and dropped the Saints to 5–6. It was the Saints’ fourth straight loss. The Bills finished 2021 at 11–6 and lost in the Divisional round. The Saints finished 2021 at 9–8 and missed the playoffs.
In their previous meeting, the New Orleans Saints won 47–10 on November 12, 2017. When they met again, the Buffalo Bills won 31–19 on September 28, 2025.
Written by WHYNFL from the final scores in its results archive, which begins with the 1999 season. Records, streaks and season results count regular-season and playoff finals.
Series Saints lead the series 5–1 after meeting No. 6 since 2001 Full series history
Jefferson returns from the ankle sprain that cost him the win over Miami, while Minnesota holds Addison and Odell Beckham Jr. out against the Saints.
New Orleans will add its greatest quarterback to the Superdome's Ring of Honor on Sunday, two months after his first-ballot enshrinement in Canton. He also receives his Hall of Fame ring during the ceremony.
New Orleans also called up receiver Cedric Tillman and tackle Easton Kilty from the practice squad for Sunday's home game against Minnesota.
